The Roaring Twenties in America Essay - 2893 Words

The Roaring Twenties in America In the first three decades of the twentieth century America became the richest and most powerful country in the world. America had so much money it could lend money to Europe after World War One. The average wage for an American was five times more than the average workers wage in Europe. Americas wealth, population and industry boomed. The 1920s are often known as the roaring twenties in this essay I will find out if this is true. The boom in America had a lot to thank for mass production. Many products were being mass produced quickly and cheaply thanks to the production line which Henry ford started at the start of the 20s this created a massive boom in†¦show more content†¦The car industry benefited a lot of people in the 20s because people could travel to other states so money was made through gas stations, shops and restaurants along side roads, which opened new job opportunities as there was 7 billion gallons of petrol used by cars on the road every year. Hotdog stands and motels also sprang up creating even more jobs. There was one car owned by one in every 4.5 persons so money was also made by tourism from people travelling around America. The car business was only bad for a few people like the workers in the factories who would age prematurely due to the same boring work every day. Public travel operators and workers suffered because fewer people needed to use buses or trains to get around . The car business improved the opportunities for those who could afford a car. As demand for cheep cars increased the cost of production decreased as factories became more mechanised and theyre for required a smaller work force. There were no blacks or Jews allowed working in the production lines and there were no trade unions to support the workers. The workers id get paid well ($5 a day) but they had to work long hours, the work was also physically exhausting and they owners of the companies made such a profit they could afford to give theShow MoreRelatedThe American Dream And The Roaring Twenties1336 Words   |  6 PagesDream and the Roaring Twenties The 1920’s was knows as the Roaring Twenties or the Jazz Age because of all the dramatic political and social change, more people lived in cities rather than farms, and the nation’s wealth doubled between 1920 and 1929. There were many new technological innovations and many factors that made the United States the place to be to find the â€Å"American Dream†. The 1920’s were known as the Roaring Twenties or The Jazz Age because of many things. The roaring twenties was a differentRead MoreAdvancements During The Roaring Twenties Essay527 Words   |  3 PagesThe twenties in the United States are thought to be full of prosperity, music, dancing, and happiness. The 1920’s are often referred to as the â€Å"roaring twenties,† but many histories purpose that this is not a correct interpretation of this time period. America may have not been good for the some of the lower class in this time period, but the 1920’s were fantastic for most of the middle and upper class living in urban cities. The advantages of this time period did outweigh the bad, which is whyRead MoreRoaring Twenties in American Society After World War I. Essay645 Words   |  3 Pageslasted from 1914 -1918, but America did not become involved until 1917. After World War I, American society changed greatly. A new era, the Roaring Twenties, found its way in America along with the arrival of the flappers (Roaring). Americans were introduced to new fashion styles, the prohibition and the Jazz Age (Fashion, Jazz). Controversy proved to be very prominent with the Scopes Trial (Scopes). As the war came to a close, the Roaring Twenties made its way into America. This time period broughtRead MoreThe United States Of America Hit An All Time Low During The Roaring 20 s With The Presence Of954 Words   |  4 PagesCinevert 1 Outline The United States Of America hit an all-time low during the Roaring 20’s with the presence of prohibition and organized crime. I. The Jazz Age Jazz Music Dance Appliances II. The New Women KKK Flappers 19th Amendment III. Mass Culture More Spending Money .First Radio Affordable Consumer Product ( Automobile) Read MoreThe Roaring 20s Essay examples655 Words   |  3 PagesThe Roaring Twenties In the 1920’s, America was evolving into a fun, carefree, and entertaining country – or so many people thought. On the outside, many people observed Americans with prosperity, lavish lives, and new opportunities through new technology and inventions. However, although America seemed to be well off at the time and enjoying life, it was only a slight cover up. Inside the country, there was turmoil which included debt and war. For this reason, America earned the reputationRead MoreAnalysis Of Babylon Revisited By F. Scott Fitzgerald1240 Words   |  5 Pagesknown as the â€Å"Roaring Twenties†. As Fitzgerald unravels the narrative, he creates a setting more representative of the time the story was written in. The underlying feeling of depression and loneliness contrasts with Charlie’s lifestyle creating an interesting clash of 1920s consumerism and the conservative culture Americans shifted towards as a result of the economic downturn. Babylon Revisite d is a strong culturally relevant piece which explores American culture from the â€Å"Roaring Twenties† to the GreatRead MoreChanges in Fashion During the Roaring Twenties705 Words   |  3 PagesVictorian age to the roaring twenties to today. The most dramatic change was from the Victorian age to the 1920s. The roaring twenties ideals of beauty and fashion are similar to todays society by what women do to their bodies, what women wear, and how women see themselves. Every women can find something wrong with her body. Women try to change, fix, or hide what they do not like about themselves. Women express what they love about their bodies as well. Therefore the roaring twenties ideal of beautyRead MoreOverview of the Roaring Twenties1383 Words   |  6 PagesThe â€Å"Roaring Twenties† were an age of dramatic political, social, and economic change. Women wanted new and improved rights and the nation’s wealth doubled between 1920 and 1929. Culture, values, and the technology of America changed and it had only just begun. The â€Å"Roaring Twenties† were considered as a â€Å"celebration of youth†. The many experiences that came from WWI had transitioned into the growth of cities, new industries, and new morals. Women finally won the right to vote in 1920, and thereRead MoreRoaring Twenties : A Decade Of Extravagance939 Words   |  4 PagesRoaring Twenties: A Decade of Extravagance The Roaring Twenties was a time of fun and delight the stock market was booming and America was thriving while other countries were experiencing turmoil in aftermath of the First World War. Returning from the horrors of war, writers were inspired by romance and the riches America had. Using their unique creative expression, many of the writings from the Twenties were a commentary on social life, the good and bad. Each story holds a different theme, differentRead More Great Gatsby by Scott Fitzgerald Essay1122 Words   |  5 PagesGatsby by Scott Fitzgerald The 1920s is the decade in American history known as the â€Å"roaring twenties.† Scott Fitzgerald’s novel The Great Gatsby is a reflection of life in the 1920s. Booming parties, prominence, fresh fashion trends, and the excess of alcohol are all aspects of life in the â€Å"roaring twenties.†   Ã‚  Ã‚  Ã‚  Ã‚  The booming parties in Scott Fitzgerald’s The Great Gatsby reflect life in America during the 1920s. Gatsby displays his prominent fortune by throwing grand parties. From next

Essay on Marketing Internship Final Report - 3102 Words

MKT 353 Marketing Department Internship Final Report Fall 2004 1. Brief description of the company and its marketing strategy. Bolthouse Farms is a family company known for their quality premium fresh produce and innovation. They are a 4th generation family farm since 1915. As a leader in their industry, Bolthouse Farms is the #1 baby carrot producer in the world. With over 2,400 employees, the company produces over 35,000 tons of carrot products every month. After more than 85 years of farming, the company recently developed a new line of delicious yet healthy fruit and vegetable juices. They figure that what better way is there to get the five servings of fruits and vegetables a day than in a convenient†¦show more content†¦After collecting product data from visiting the stores, I would type up reports with all the gathered information including any important relevant details and send it to my supervisor. As the company was changing and expanding, my responsibilities changed as well. As Bolthouse Farms and Krogers formed a relationship my initial job was to research the Krogers Signature stores in the Houston area until the orders were complete and the juice was in the store. My second major responsibility was performing demonstrations. The first image that popped into my head when Sarah told me about this task was a vision of me as a sample lady dressed in an apron handing out samples of Bolthouse Farms juice. For the most part my image was correct. It turns out this responsibility was not as unglamorous as I had first thought. I spent much of my summer holding these demonstrations at Whole Foods Market with whom Bolthouse Farms had a really good relationship. During the peak hours of these demonstrations, strategically held during busy lunchtimes, a crowd would gather from hearing about all the good feedback from taste testers and loyal customers of Bolthouse Farms. I had first thought this part of my internship would be the most embarrassing or boring. However, this was actually the mostShow MoreRelatedInternship Report1292 Words   |  6 PagesEconomics and Finance | MiBA Master of International Business Administration INTERNSHIP REPORT AT PALYTRA TRAVEL AGENGY Table of Contents 1. Explanation about how the internship was applied. 3 2. Description of the firm and the department. 3 3. Description of job and tasks during the internship. 4 4. Connection between study and practice. 5 5. Working Routine. 5 6. Supervision. 6 7. Expectations. 6 8. ResultsRead MorePersonal Statement : Griffin Communications Group1655 Words   |  7 Pageslast I would like to thank Kenneth Mays, account executive and internship supervisor for giving me the opportunity to be part of this interesting internship and work alongside him in various projects. I will forever be grateful to have him as mentor and friend. Overview of Griffin Communications Group Our primary objective is to exceed client expectations in terms of quality, value and results. 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Students can earn work experience by participating in an internship. Interning in a field of choice will stand out on a students resume and help them with their job search after graduation. Participating interns gain on-the-job training that integrates education, careerRead MoreInternship Report On The Internship1702 Words   |  7 Pages FINAL INTERNSHIP REPORT September 4 2015 BUSN 615 Internship Course Period: July through September 2015 Drexel ID: 13820722 Varun Pillai FINAL REPORT FOR SUMMER INTERNSHIP WITH AUDIENCE PARTNERS Varun Pillai (267) 471-2511 E-mail: vrp36@drexel.edu Facility: Audience Partners 414 Commerce Drive, Suite 100 Fort Washington, PA 19034 Supervisor: Alex Gochtovtt Chief Analytics Officer Phone: +1-484-928-1010 Fax: +1-484-556-4161 Read MoreCollege Intern Team Lessons Learned1713 Words   |  7 Pagesorganization. In either event, this document should serve as a backdrop for any future unpaid internship opportunities at HOLT CAT. 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Responsibilities: †¢ Working with Community Leads, develop a pre- and post-launch community development strategy that fosters audience growth and retention through tacticsRead MoreEssay936 Words   |  4 Pagesthe courses I undertook related to data, I did an internship at Apra Auto (India) pvt. Ltd in my 3rd year. During the internship, I worked in the EDP- Electronic data processing department and managed the database of inventory and stock of the company. I also worked on Data Flow Diagrams (DFD) to create an overview for data processing and database design. Following this I did coding using C++ Object oriented programming concepts. 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Firstly, the marketing manager needs to have a bachelor’s degree, ten years marketing experience and minimum of five years of people leadership experience. The leadership skills means the manager can provide exceptional people management and leadership abilities

Another Day, Another Nickel Free Essays

Angie Navarro Castillo Composition I Karla Whitehurst Another Day, Another Nickel As I’m driving on Interstate 30 going to work at the restaurant Country Fare, I stare at the beautiful mixture of colors displayed in the sky. Pink, orange, yellow and blue mixed all together in a breathtaking sunset in Arkansas. I get off exit 44. We will write a custom essay sample on Another Day, Another Nickel or any similar topic only for you Order Now The time is getting closer and I pull over on the parking lot and I see the big sign that says TA. The time has arrived and now I have to work. It may not be the most exciting place for me to be, but if I want to be able to pay my bills, this is where I need to be. I go through the glass door and I say hi to the guys working at Subway right in front of the entrance, then I turn right and walk by the buffet and my shift 4pm to midnight is officially started. Soon after I clock in I must count my drawer, which today is full of different coins, therefore it takes me a while to count it this time. As I am finally ready I start helping customers and taking orders. The place wasn’t quite busy when I first got there, but half an hour later the restaurant is packed. There are lots of truck drivers starving and anxious to eat and leave. There are no TVs or anything to entertain them, which makes them bored. The dining room is plain and white with few decorations of Saint Patrick’s Day hanging around. All the tables and chairs in the bar are full with customers. I try to help everyone as fast and efficient as possible, the cook in the line is working hard as well. He is yelling the waitresses’ names with every meal when it’s ready to deliver. Tonight there are only two waitresses on the floor; we are both walking back and forth trying to get this dinner rush over with. There are 2 cooks for the buffet and a dish washer guy was not scheduled, consequently the manager is helping with the dishes so we don’t run out of dishes and glasses. I am getting behind, many tables remain dirty and more customers walk in as soon as some walk out. The atmosphere that once was the background music is now filled with conversations; it’s just blah, blah, and blah. Its only 8 o’clock, and I need to catch my breath for a second, I drink some Pepsi cola. While delivering the steak dinner and pasta to table 12, I just get very hungry. By this time I wish I could take a break, but since there are only 2 of us, I can’t, even though I snack on some crackers while cashing out some customers. I run out of one dollar bills, so I ask the manager on duty to get me the cash. When he comes to the dining room, he realizes how busy we are and finally he helps me bussing some tables. Once I got some help the dining room looks better and less busy. I feel better because I don’t have to run back and forth as much. When it gets as slow as this, it’s time for me to do my side work. I have to sweep, mop, and do fill-ups. Ketchup bottles are almost all empty. I have to fill them up and do so with the sweeteners and jellies. Barbara, the graveyard waitress, has arrived, which means it’s time for me to leave. All I have left to do is bring a bucket with ice and fill up the soda machine. I am now ready to count my register and leave. After the shift is over, the restaurant looks calmer and roach free. The only relief that makes my day is to look at my pocket in my apron and see it full of dollars, reward of my hard work. Therefore I say: Another Day, Another Nickel. How to cite Another Day, Another Nickel, Papers

Effects of Rap Lyrics on Youth free essay sample

One study found that young subjects who watched violent rap videos were more accepting of violent actions, particularly against women. Additionally, those who watched either violent or nonviolent rap videos were more Inclined to express materialistic attitudes and favor potentially acquiring possessions through crime, as well as holding more negative views on the likelihood of succeeding through academic pursuits. Another study found that adolescent females, after watching a rap video depicting women in sexually subordinate roles, were more inclined to express acceptance of lenience against women in a dating situation. However, increased acceptance of crime and violence appears to be linked with viewing violent or sexist rap videos rather than listening to rap music on its own Read more at Suites: Rap Musics Psychological Effects: Research into Mood, Behavior, Crime, Violence and Gender Relations I Cultures . Mom http:// eleemosynary 101 . Com/rap-music-psychological-effects-a 53370#lezzy Kludge Although research has found a correlation between preference for heavy metal or rap music and behavioral problems, drug or alcohol use, arrests and sexual romanticist, these behavioral problems usually begin before students begin listening to rap or heavy metal, which indicates that the music does not cause behavioral problems or addiction. We will write a custom essay sample on Effects of Rap Lyrics on Youth or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Rather, it suggests that at-risk youth are more inclined to prefer heavy metal or rap music.Behavior, Crime, Violence and Gender Relations I Suites . Com http:// eleemosynary. Salute 101 . Com/rap-music-psychological-effects-a 53370#Liz 1 Skimmers Listening to rap or heavy metal has not been shown to increase suicidal ideation and anxiety or adversely affect self-esteem among college-aged men and women. Oddly enough, students listening to a nonviolent rap song experienced more depressive symptoms than those who listened to a violent rap song. Overall, rap songs are more inclined to generate angry emotions than heavy metal songs, however. Unemployable 101. Com/rap-music-psychological-effects-a53370#Liz 1 Cumulus Effects of Rap Lyrics on Youth ay Stodgily Matched either violent or nonviolent rap videos were more inclined to express materialistic attitudes and favor potentially acquiring possessions through crime, as Nell as holding more negative views on the likelihood of succeeding through Omen in sexually subordinate roles, were more inclined to express acceptance of idiolect against women in a dating situation. Effects of Rap Lyrics on Youth free essay sample Another study found that adolescent females, after watching a rap video evicting women in sexually subordinate roles, were more inclined to express acceptance of violence against women in a dating situation. However, increased acceptance of crime and violence appears to be linked with viewing violent or sexist rap videos rather than listening to rap music on its own Read more at Suite: Rap Musics Psychological Effects: Research into Mood, Behavior, Crime, Violence and Gender Relations I Suite . Mom http:// confirmedly. Suite 1 01. Com/rap-music-psychological-effects- 53370#ixzz1jKL52dhg Although research has found a correlation between preference for heavy metal or rap music and behavioral problems, drug or alcohol use, arrests and sexual promiscuity, these behavioral problems usually begin before students begin listening to rap or heavy metal, which indicates that the music does not cause behavioral problems or addiction. Rather, it suggests that at-risk youth are more inclined to p refer heavy metal or rap music. We will write a custom essay sample on Effects of Rap Lyrics on Youth or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Read more at Suite : Rap Musics Psychological Effects: Research into enforcedly. Suites 01 . Com/rap-music-psychological-effects- a53370#ixzz1jKMss15k Mood Listening to rap or heavy metal has not been shown to increase suicidal ideation and anxiety or adversely affect self-esteem among college-aged men and women. Oddly enough, students listening to a nonviolent rap song experienced more depressive symptoms than those who listened to a violent rap song.

At Various Times In The Geological Past Essay

At Various Times In The Geological Past Essay At Various Times In The Geological Past Essay â€Å"At various times in the geological past, many species have become extinct as a result of natural, rather than human, processes. Thus, there is no justification for society to make extraordinary efforts, especially at a great cost in money and jobs, to save endangered species." Extinction of species in the geological past might be due to natural phenomenon but the present is quite different. Although natural phenomenon, like floods, landslides, earthquakes are potent to cause extinction of species, with improvement in technology and advancements in research field humans have become invasive enough to effect the same. For eg. habitat destruction, hunting , use of toxic chemicals, industrialization all account for extinction of species. Also, global warming and acid rains are natural processes which are effected by humans. Global warming leads to climatic and temperature changes and ultimately may cause floods leading to loss of various species. Even Acid rain is adversely affecting many plant species and accelerating their loss. Being the most active and intelligent animal on Earth it’s our responsibility to maintain the ecological equilibrium. Each species is dependent on every other species for its survival. And many of them form important links in the nature’s cycles. If those links are lost the nature’s harmony will be disrupted. One must not forget, Humans themselves rely on other species to fulfill their basic needs as well as extravagant desires. Various products like

The History of APA Writing Style

The History of APA Writing Style Have you been asked to prepare a report or research paper, and its been so long since youve written one, youve forgotten how? Maybe you simply havent ever learned the proper way to create a paper with secondary sources. Perhaps its simply been so long since you wrote a research paper that the rules have changed. Whatever your situation, APA writing is a good, solid place to start. You can create a sound, standard paper using the APA writing style. Using documentation for secondary sources, and some finer points of writing, you can make first-rate papers and reports, every time. The American Psychological Association established a style that it uses in all of its publications. This APA style has been adapted by many colleges, businesses, and institutions because of its stellar documentation system. You can learn the intracicies of APA easily nowadays by finding the best APA formatting software to instantly conform your paper to APA requirements. Using APA writing, you can be sure to have the correct format for all your report needs. From punctuation and abbreviations to construction of tables and presentation of statistics, you can create a paper that is easy to read and looks sharp. Moreover, you can be sure that whoever grades or edits your paper will find little wrong with its format.

Security in Electronic Voting Systems Essay Example | Topics and Well Written Essays - 1750 words

Security in Electronic Voting Systems - Essay Example Though electronic voting systems are highly efficient and accurate, security of the systems is of high concern. Security in electronic voting is core in the terms of confidentiality of voter information and prevention of malicious or accidental abuse of electronic voting (Liaw, p 110). Electronic voting systems must be efficiently designed to maintain high confidence levels and integrity in order to eliminate voter manipulation, and the manipulation of the electronic voting at large (Liaw, p 115). The electronic voting system should be capable of separating the data content from its presentation form to avoid replication of the web content. This is ensured by the use of modern technologies in the system design, such as the extensive markup language for the web representation of the data content and the extensive language transformation style sheets for the customization of the data presentation. Electronic Voting Security Requirements Confidentiality: The electronic system must be ap propriately designed to ensure the confidentiality of voters’ personal information. ... Authentication: The system must ensure that the voter is efficiently identified, as per the registration database, to be entitled to and allowed to vote. Appropriate identification documents may be required for clarification of voter identity (Bungale & Sridhar, p2). The voter must identify him/herself as per the system’s voter registry to be able to vote, and hence an elimination of fraudulent voting and manipulation of the electronic voting (Bungale & Sridhar, p2). Anonymity: On the other hand, the electronic voting system must also ensure that votes are not associated or identifiable with voter identity. The system should also be non-coercible, that is, voters should not be able to prove to others on how they voted. This eliminates vote selling and/or coercion (Bungale & Sridhar, p2). Verifiability: The electronic voting system should be able to efficiently verify voters for voting, after identification. Additionally, the system should also be able to verify the results to ensure accuracy, including the number of voters who participated and the total number of votes cast. The system should be reliable and robust to eliminate the loss of votes, despite any technical failures such as loss of network communication (Bungale & Sridhar, p2). Cryptographic Chimes of an Electronic Voting System The cryptographic voting protocols ensure and facilitate verifiable voting without fundamentally trusting any software in the voting system. However, cryptographic protocols may cause challenges to the voting system, such as denial of service, compromise on voter confidentiality and creation of subliminal channels in the encrypted ballot. In addition to analyzing the

The Crusades Essay Example | Topics and Well Written Essays - 1250 words - 1

The Crusades - Essay Example They left for Acre in 1217, and joined John of Brienne, ruler of the Kingdom of Jerusalem, Hugh I of Cyprus, and Prince Bohemund IV of Antioch to fight against the Ayyubids in Syria" (Crusade, Wikipedia). The campaign started with seizes of Damietta, in June, 1218 and they gained little success with conquering one tower outside the city on 25th August. But then epidemic swept through the crusader's camp and one of the many casualties was Robert of Couron. But by November the crusaders were able to capture the sultan's port under Francis of Assisi. He tried to negotiate with the sultan numerous times but failed. Slowly but surely the crusaders were gaining footholds in their campaign and ultimately seized Cairo. But their march to Cairo was proved to be disastrous as it was the flooding season of the Nile and "with supplies dwindling, a forced retreat began, culminating in a night attack by Al-Kamil that resulted in a great number of crusader losses and eventually the surrender of the army by Pelagius. The terms of this surrender meant the relinquishing of Damietta to Al-Kamil and an 8 year peace agreement with Europe in return for the original piece of the cross and the prisoners held from the failed advance on Cairo". (http://en.wikipedia.org/wiki/Fifth_Crusade) The Sixth Crusade: The Emperor Frederick II of Germany had taken the crusading vow when he was young during his coronation ceremonies. And now it was his turn to salvage the holy land. The Kingdom of Jerusalem was ruled by John of Brienne who was actually had been acting as king. Fredric married his daughter Yolanda and started his campaign in 1228. Though Fredrick was barred considerably with internal conspiracies and movements he was able to force Al-Kamil, the sultan of Egypt into negotiation thereby winning the possession of Nazareth, Sidon, Jaffa, Bethlehem, and all of Jerusalem except the Dome of the Rock in February 18, 1229. Fredrick was not allowed to rebuild the wall of Jerusalem, destroyed by Al-Mu'azzam, nephew of Saladin, in 1217 but he entered in to the city victorious and was crowned king on March 18th. But due to constant restraints by the conspirators back home Fredrick left Jerusalem in May and in 1244 when the truce ended Jerusalem was taken by the Mamluks. The Seventh Crusade: The Seventh Crusade was started by King Louis IX of France. For his campaign to recover the holy land King Louis IX became known as Saint Louis later in his life. Some scholars believe that this title was given to him simply because of his great devotion to God and not for his crusade campaign. The Mamluks took possession of Jerusalem in 1244. Louis felt it was his duty to announce his version of Crusade. King Louis IX of

Corporate Finance Assignment ( Questions ) Essay

Corporate Finance Assignment ( Questions ) - Essay Example The Enron scandal and Arthur Anderson case has been the witness of this testimony. If the interest of organisation and individuals are not aligned then there are classical cases like Arthur Anderson and Enron comes up in the public world. This case tries to highlight how a corporation like Arthur Anderson came to such demise. 80 years of legendary innovative history in Corporate America that was created by Arthur Anderson was washed up in a matter of 8 years. Internal divisions came up in the company and the world started to look at Corporate America with shame. To align the principal agent theory in practice, Sarbanes Oxley came into operation in 2002. The act tried to align the best interest of the shareholders and the agent i.e. Management in the same mould. The objective of the act was to reduce the ever growing gap between the two of the main functions of the organisation. There are two main functions of any organisation which decide the fate of the organisation as a whole. The first one of them is the shareholders (Principals) who elect the Management (agent) to represent them as the owner of the company. The objective of the principal is to maximise shareholders wealth while that of Management can be the same or it can be different also. If the objectives are aligned by using good compensation strategy and urging responsibilities over the management then agency cost of the company will be reduced. If that is not the case agency cost will always increase. With this background let us have a look at the classic case of Arthur Anderson. Management of the company which was looking after the AA division of the company was less compensated compared to their counterparts in AC. This is itself a contradiction to the principal agent theory. Arthur Anderson has grown from the roots as a major auditor and the consulting division came into picture very late when they started automating the book keeping systems. AC was very successful and the compensation was not in a lignment with the kind of success they achieved. Hence the companies were separated and consulting division was now separate from auditing division. After the separation AC kept growing fast with their own set of compensation strategy while AA started facing challenges. This challenges are advent from the number of lawsuits AA faced during 1990s and 2000. Employees at AA were resenting and finding other ways to get paid and rope in extra money for the organisation and themselves. This is when they started realigning shareholders interest with theirs. This was visible in the biggest corporate scandal of America- Enron. Enron was the worst corporate scandal which shook American Corporation. Auditors at Arthur Anderson signed the financial statements of Enron without cross checking the stated facts. This was done just to rope in extra money from this big ticket client. Somewhere this is an also a case where organizational structure should be questioned. The reason for this is because f or a big ticket client like Enron, Arthur Anderson compromised its corporate hierarchy. They allowed their premier groups to go and reside at the client’s headquarter. There was no proper check on what was happening within employees and the client. 2- (Goal of financial Management )Why is the goal of financial management to maximize the current share price of the company‘s stock? In other words, why isn’

The Process Of Hematopoiesis And How Its Controlled Biology Essay

The Process Of Hematopoiesis And How Its Controlled Biology Essay In humoral mediated response of the immune system, the clonal proliferation results into antibody secreting plasma cells and memory B-cells. The primary response has a lag of about 5-7 days during which the B-cells becomes activated by the antigen and T-helper cells. During the lag period, differentiation and proliferation of B-cells takes place into plasma cells. Antibody level begins to increase and reaches its peak at about day 14 and the drop begins once the plasma cells die. In the secondary response, clonal expansion of memory B-cells takes place and the antibody levels are much higher. These memory cells respond more rapidly to the antigen. Moreover, since many memory cells are present for the primary response, the number of plasma cells generated are more in the secondary response and the antibody levels are higher [2].   3.Briefly describe the functions of the following cells of the immune system; dendritic cells; macrophages; neutrophils; T helper cells. Ans) Dendritic Cell These cells resemble the dendrites of the nerve cells and have a long membrane extensions. They can be either present on the epidermis (skin) and mucous membranes (langehans cell) ; heart , lungs, kidney, GI tract (interstital dendritic cell) ; T-cell are of secondary lymphoid and thymic medulla ( Interdigitating dendritic cell) and in blood and lymph (circulating dendritic cell). They represent high levels of class II MHC molecules. Dendritic cells are APCs. They engulf the antigen by phagocytosis/endocytosis and carry it to the various lymphoid organs where they represent the antigen to T lymphocytes [2].    Macrophages They arise from monocytes. It functions as a scavenger that ingest debris, damaged and dying cells as well as foreign organism. They either contain class II MHC molecules or the co-stimulatory B7 membrane molecules. Once the foreign organism is inside the macrophage, they are either killed by lysosomal enzymes or by O2 free radicals which is released by phagosomes[1].   Neutrophils They are active phagocytic cells and always reach the site of inflammation. The foreign body is killed by the various lytic and bactericidal substances which are present within the primary and secondary granules. They employ both O2 dependent and O2 independent pathway to generate antimicrobial substances. It is better than macrophage since they exhibit larger respiratory burst and express higher level of defensins [2].   T-helper cells-   T-cells are formed in the bone marrow but mature in the thymus. There are two types of T-cells- TH and TC .TH cells have CD4 whereas TC has CD8. The TH cells gets activated when the cell recognizes and interacts with an antigen. After it is activated, it forms into an effector cell and secretes growth factors known as cytokines. These cytokines play an important role in activating B cells, Tc cells, macrophages and elicits an immune response. Different types of immune response occurs due to different types of cytokines[2].   4) What are the two fundamental approaches to drug discovery? Ans) The two approaches to drug discovery are rational drug design and molecular diversity. Rational drug design The drugs work in the body by interacting with the receptor and they alter the activities in such a way that it brings about a betterment of the body. This method uses the information about structure of the drug receptor or create a candidate drug. The 3-D structure of the protein can be determined using methods such as X-ray crystallography or nuclear magnetic resonance spectroscopy. The researchers in the pharmaceutical industry can use whatever information is available on the databases and find a chemical compound which can react with the receptor and can be tested in the labs. If the interacting compound cannot be found then other programmes can be used to find the compounds with similar properties to known ligands. This method is done to avoid the expenses. The first drug produced by this method is Relenza which is used to treat influenza. The other drugs developed to treat HIV infections are Ritonivir and Indinavir [3]. Molecular diversity The strategy applied in molecular diversity is the isolation of bioactive molecules molecular libraries such as nucleic acids, amino acids and small organic molecules. The main goal is to isolate molecules from libraries of chemical compounds or proteins and study the structure or shape of their target with the binding with affinity and specificity. The anti-inflammatory mAb Humira is a biolgic isolated from molecular diversity.   5. How does the flu virus infect cells? Give a brief overview of how the flu drug relenza was discovered. (Note :   Relenza is not as biologic but a small molecule drug). Ans) Influenza viral particles are surrounded by an outer envelope a lipid bilayer which they acquire from the plasma membrane of the infected host cell during the process by budding. In the envelope the two glycoproteins which are present are Hemagglutinin (HA) and neuraminidase (NA). HA is responsible for attaching the virus to the host cell. HA is a trimer and it binds to the sialic acid groups on host cell glycoproteins and glycolipids by conserving the amino acid sequence to form a small groove in the HA molecule. Neuraminidase cleaves N-acetylneuraminic (sialic) acid from the viral glycoproteins and the host cell membrane glycoproteins. This facilitates viral budding from the infected host cell. Once the virus is inside the host cell, the HA binds to the walls of the endosome (acidic nature) because of which the viral coating collapses. Within the envelope, matrix protein surrounds the nucleocapsid   which consist of 8 different strands of single stranded (ssRNA) and are ass ociated with protein and RNA polymerase. Once inside the cell, the RNA strand encodes one or more different influenza proteins. Many copies of the virus are made in the nucleus and then it moves to the cytoplasm to form viral proteins including HA and NA. The new viruses which are formed move out of the cell by forming buds and moving out against the plasma membrane[2].   Relenza This drug is created by using rational design. The discovery was funded by the Australian biotech company Biota. The structure of neuraminidase was known by X-ray crystallography. A competitive inhibitor which is a sialic acid analogue, is an inhibitor of neuraminidase. The general function of neuraminidase is that it cleaves sialic acid from the virus and the cell surface and prevent clumping and allows the virus to spread to other cells. Relenza induces clumping and reduces viral spreading. 6.What is meant by pharmacogenomics and how might pharmacogenomics be applied to drug development in the future? What is an example of a biologic where patient genetic profiling is used to evaluate the suitability of the patient for therapy? Ans) Pharmacogenomic is the study of the roles of genetic variation in the response to drugs. It includes information from genomics, proteomics, bioinformatics and other disciplines such as biochemistry and toxicology in order to synthesize newer and safer drugs. As the sequences of all our genes and the protein they encode for are determined, this will reveal many new targets for drug actions. It also reveals polymorphism of enzymes and proteins related to drug metabolism, action and toxicity DNA probes which are capable of detecting them will be synthesized, permitting screening of individuals for potentially harmful polymorphism prior to the start of the therapy. As the structures of relevant proteins and their polymorphism are revealed, model building and other technique will permit the design of drugs that take into account both the normal protein targets and their polymorphism. In simple words, the drugs will be tailor-made for individuals based on their genetic profiles[4]. Th is is the application of pharmacogenomics in drug development. The example where genetic profiling is used to evaluate the suitability of the patient is ERBB2 is a 185 kDa tyrosine kinase receptor over expressed in approximately 25-30% of human breast cancer .   7. Give an example where over expression of a cytokine results in a disease state. What biologics, if any, have been developed to treat this disease state? Ans)   Rheumatoid arthritis is a an inflammatory disease. The major symptom is chronic inflammation of the joints including shoulders, ankles, elbows and knees. It is characterized by the inflammation of the synovium along with the the destruction of the joint cartilage and bone. The over expression of cytokines such as TNF, IL-1, IL-8, IFN ÃŽ ³ have been detected in the synovial fluid. Cytokines such as TNF activate the synovial cells which produce proteolytic enzyme such as collagenase which leads to the destruction of tendons, ligaments and cartilage. The cytokines are produced due to the activity of T cell and macrophage activation.   A number of biologics have been approved for treating rheumatoid arthritis[5]. They are cimzia, enbrel, humira, kineret, orencia, remicade, rituxan and simponi[6].    Rituxan Rituximab is sold under the trade name Rituxan. Rituxan is a chimeric monoclonal antibody against the protein CD20 which is found on the surface of B cells. Rituxan when given in combination with methotrexate is given to adult patients with minor to acute conditions who had an inadequate response to one or more TNF antagonist therapies. The side effect of rituxan is that patients show hypertension, nausea, upper respiratory tract infection, pyrexia etc.[7] .   8. Interferons are used as biologics to treat viral infections. How does interferon induce the anti-viral state in cells? Ans) Interferons are antiviral and show their effect in a signaling pathway. There are two types of interferons, type I and type II. IFN-I is produced by cells under appropriate conditions including IFN-ÃŽ ±/ÃŽ ². IFN-II are produced by a few number of cells such as NK cells, T-helper cells and dendritic cells. IFN-II includes IFN-ÃŽ ³. IFN-I plays an important role in the innate antiviral response. IFN-ÃŽ ±/ÃŽ ²is responsible for inducing the anti-viral activity by binding to IFN receptor on the cell surface, which leads to activation of receptor-associated JAKs (Janus Kinase) such as JAK-1 and TYK-2. This activates the STATs (signal transducer and activator of transcription) due to phosphorylation which leads to the formation of ISG factor (ISGF)-3 complex which consists of STAT-1 and -2 and p48. After phosphorylation at Tyr701 and 692 of IFN receptors by IFN-1, STAT-1, and -2, there is formation of a heterodimer which translocates to the nucleus and forms an association with p48(I RF-9).   The complex (STAT-1 and -2 and IRF-9) is called as ISGF-3 and it associates with ISREs to activate ISGs. The 3 antiviral proteins involved in IFN-mediated inhibition of virus infection are : 1)  Ã‚  Ã‚  Ã‚  Ã‚   The Rnase L pathway which degrades viral RNAs and then activates dsRNA. 2)  Ã‚  Ã‚  Ã‚  Ã‚   PKR inhibits mRNA translation by phosphorylating translation initiation factor 3)  Ã‚  Ã‚  Ã‚  Ã‚   Mx proteins possessing GTPase activity which restricts virus infection at many stages such as primary transcription, transcription and intracellular trafficking of viral proteins or genomes. Thus, interferons induce the anti-viral state in cells[8].

Lowering Testing Standards in Third World Countries Essay -- HIV AIDS

Lowering Testing Standards in Third World Countries ABSTRACT: Recently, Sidney Wolfe, director of Public Citizen’s Health Research Group (PCHRG), charged the National Institute of Health (NIH) and Center for Disease Control (CDC) with sponsoring fifteen immoral HIV studies in sub-Saharan Africa. The trials are being conducted to determine if certain alternate medical procedures or a short course of treatment with AZT, zidovudine or other drugs prevent some mother-child HIV transmissions. (1) Since the control group receives only placebos rather than AZT, Wolfe claims that the tests give suboptimal treatment that will result in more children contracting HIV and AIDS. (2) Public Citizen’s Health Research Group and others are calling for an immediate cessation of these important experiments. Public Citizen raises an important moral question. (3) Is it morally permissible to lower testing standards for the Third World? Unlike PCHRG, I contend that the answer to this question is yes, if the trials meet certain conditions. I e xplain both the First Best and Second Best Method (FBM and SBM, respectively) of testing new drugs and then compare the two. Next, I show the FBM’s impracticality in developing countries releases researchers from the moral obligation to use it. I then propose a new set of criteria — the Second Best Criteria (SBC) — that show if a test is moral or not. Finally, I argue that imposing a developed country’s moral standards for clinical trials in the Third World is immorally insensitive to the needs and conditions present in the latter area. Section 1 In clinical trials there are two different standard protocols for testing new drugs. The First Best Method tests the effects of a known drug (a benchmark), rathe... ...Biotechnology, vol. 11, pp. 135-143. Pederson, Daniel and Eric Larson, "Too Poor to Treat" Newsweek, 28 July 1997, p. 60. Rath, Richard, "Horton Hears the W.H.O." Dissonance, AIDS and Africa Resource page, 3 June 1996, http:/www.way.net/dissonance/nyrb_ltr.html, pp. 1-3. UNAIDS "HIV/AIDS: The Global Epidemic", Press Release, 28 November 1996, http:/www.us.unaids.org/highband/document/epidemic/situat96.html, pp. 1-15. —— "HIV/AIDS epidemiology in sub-Saharan Africa", 3 July 1997, http:/www.hiv.unaids.org/unaids/press/factafr.htm, pp. 1-3. —— "UNAIDS Announces New Clinical Trials for the Prevention of Mother-To-Child Transmission of HIV", Press Release, 9 July 1996, http:/www.hiv.unaids.org/unaids/press/mtctpren.html, pp. 1-2 No Author Listed: "AIDS in Africa", The Guide, 9 May 1996, http://www.guidemag.com/newsslant/aids.africa.html. pp.1-2